Cancer metastatic to lymph node axilla, EXPRESSION OF BMI-1 PROTEIN IN CERVICAL, BREAST AND OVARIAN CANCER
Overexpression of Bmi-1 has been reported in various human cancers and proved to be associated with poor survival.
Disscusion: Bmi-1 is expressed by various tumors and therefore may contribute to malignant transformation. Bmi-1 not only can lead mammary epithelial cells to senescence and immortalization, but also plays a key role in breast cancer.
A significant correlation was observed between Bmi-1 expression and axillary lymph node metastases in lymph-ductal breast cancer. Bmi-1 is expressed in cervical cancer and correlated with a poorer prognosis, suggesting that this protein participates in the development and progress of cervical cancer.
Regarding ovarian cancer, the results of several immunohistochemical studies revealed overexpression of Bmi-1, especially in poorly differentiated ovarian carcinoma. There is a strong correlation between histological grade, clinical stage and its expression.
Conclusions: Human genes cancer metastatic to lymph node axilla polycomb group correlated with various hematological and epithelial cancers identify new mechanisms of malignant transformation and pave the way for developing new cancer treatments and identify new diagnostic markers.
Bmi-1 and its expression in tissues taken from patients with cervical, breast and ovarian cancer could be a marker for diagnosis and prognosis, and not least a potential target of antitumor therapy.
Sauvageau M, Sauvageau G. PLoS Biol,6 4 : e Posterior transformation, neurological, abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev ; 8: — Bmi-1 is essential for the tumorigenicity of neuroblastoma cells. Am J Pathol ; 5.
Ganglionilor limfatici axilari sunt ei decolorate.
Mihuțiu S. Corelații anatomo-clinice cu prognosticul în cancerul ovarian epitelial. Teza de doctorat, Facultatea de Medicina, Oradea Armstrong DK.
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