Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva

Papilloma virus in human

Department of Ophthalmology, Grigore T.

papilloma virus in human

E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.

The method used for the detection of HPV was real time polymerase chain reaction.

This is one of the most common sexually transmitted infections, with a tropism for tissues such as squamous or mucosal epithelium. Human papillomavirus can be classified according to the ability of oncogenesis in low-risk genotypes, associated primarily with genital warts and high-risk, associated with premalignant and malignant lesions. The immunization rates for Human papillomavirus are generally lower than for other types of vaccines, and further implementation of appropriate strategies is still needed. Moreover, the way a healthcare provider presents and recommends a vaccine can be decisive in the choice of a person to immunize or not. Keywords Human papillomavirus, immunization strategies Rezumat Infecţia cu virusul papiloma uman HPV rămâne un factor important în producerea cancerelor de col uterin, vaginale, vulvare, anale şi de orofaringe.

The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.

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The association between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.

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Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half.

He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.

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The patient admits being a heavy smoker for almost 30 years and that in his free time he practices agriculture without using sunglasses. All other ophthalmological findings were normal. Conjunctival culture was performed before surgery, and no bacterial infection was found.

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The CT scan of the head and neck showed no signs of tumor invasion of the orbit or the lymph nodes. The limbic lesion was papilloma virus in human surgically with 2 mm margin of normal tissue and diathermy of the adjacent sclera was done. At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor papilloma virus in human cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.

Cancerul este o maladie care, descoperita timpuriu, ofera un procent semnificativ de vindecari. Rata de mortalitate datorata cancerului de col uterin a scazut in ultimii ani in tarile dezvoltate, ca rezultat al depistarii precoce si a modernizarii mijloacelor de tratament. In tara noastra acest neoplasm are o incidenta scazuta, dar in multe cazuri este descoperit in faze avansate. In Romania acest cancer ocupa locul al doilea in randul neoplaziilor sexului feminin, dupa cancerul mamar.

Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.