Noi tratamente sistemice în infecţia cu HPV

Medicaments papillomavirus

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HPV is causing a variety of benign, borderline and malignant disorders, with common anogenital signs. The association of various types of treatment is still the preferred method to eradicate HPV infection. This paper offers information about possible systemic treatments of HPV infection, based on the documentation from the PubMed databaseincluding immunomodulatory drugs, antiviral medications, therapeutic HPV vaccines and biological therapy.

Keywords HPV, HPV systemic treatment, therapeutic medicaments papillomavirus, systemic immunomodulators, systemic antiviral drugs Rezumat Infecţia umană cu diferite genotipuri ale virusului papiloma uman HPV este una dintre cele mai frecvente infecţii virale cu transmitere sexuală.

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HPV provoacă o varietate de afecţiuni benigne, precanceroase şi maligne, cu semne anogenitale comune. HPV necesită tratament sistemic antiviral, dar în prezent nu există un medicament antiviral sistemic aprobat împotriva infecţiilor cu HPV.

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Asocierea diferitelor tipuri de tratament este încă metoda preferată pentru eradicarea infecţiei cu HPV. Această lucrare oferă detalii despre posibilele tratamente sistemice ale infecţiei cu HPV, pe baza documentaţiei din baza de date PubMedinclusiv medicamente imunomodulatoare, medicamente medicaments papillomavirus, vaccinuri HPV terapeutice şi terapie biologică.

Cuvinte cheie HPV tratament sistemic HPV vaccinuri medicaments papillomavirus imunomodulatoare sistemice medicamente antivirale sistemice Genital infections with human papillomaviruses HPVamong the most common sexually transmitted diseases STDgenerate alarming signals in human health, due to the prevalence and dissemination, as well as to various pathologies induced mostly at the level of the genital tract medicaments papillomavirus.

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The virus has tropism for feminine genital tract. Discussion At this moment, there is no routine effective therapy to treat lesions induced by HPV.

HPVshr infection with various clinical forms at various levels requires an early diagnosis and proper treatment 5. The treatment improves symptoms, especially regarding evolutive flares, lowering the possibility of infection by HPV and possibly medicaments papillomavirus other possible STD associated 6. It is recommended that all clinical medicaments papillomavirus subclinical susceptible lesions at the level medicaments papillomavirus epithelium and mucous membranes be tested for HPV 7.

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The possibility of identifying the genotype is useful, especially for infections with HPVshr, when the therapy must be prompt and targeted, and post-therapeutic follow-up must be done medicaments papillomavirus long term in order to prevent the neoplastic transformation 8.

Taking into account the fact that many medicaments papillomavirus with confirmed HPV etiology have a self-limiting evolution, it is recommended that before starting the treatment the patient should be kept under observation for several weeks, expecting the spontaneous healing 9.

A multidisciplinary approach is required for optimal decision making, treatment planning, and post-treatment response assessment. The therapy of the infections produced by HPV is local and systemic. Topical treatment removes lesions, but the absence of infection is not guaranteed The absence tratamentul helmintelor bolii crohn a sterilizing therapy diminishes the effectiveness of evaluation and monitorization of the sexual partners, but their testing can identify ignored lesions HPV is ubiquitous, especially in the lower genital tract, which makes the pharmacological treatment to be considered as the therapy of choice The treatment with interferon and immunomodulating agents inosine did not bring the presumed results many side effects which limited the therapeutic doses Figure 1.

Infectia cu HPV (Human Papilloma Virus)

Antiviral polyamide in HPV infection 18 Systemic antiviral treatment would be the treatment of choice, but at present there is no systemic antiviral drug approved for HPV This article details the progresses in the treatment of systemic infection with HPV, regardless of type, location and genotype Table 1. HPV vaccines currently licensed in the United States of America 21 This paper provides up-to-date scientific data on the medicaments papillomavirus systemic treatments of human infections with HPV confirmed etiology.

Recurrences occur after all medicaments papillomavirus.

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  • Medicaments papillomavirus. B. PROSPECTUL

All topical treatments are associated with local skin reactions including itching, burning, erosions and pain. A number of studies highlighted the role of HPV systemic treatment, from which the most prevalent are aromatic retinoids, interferon, inosine, while other studies have reported benefits after using hydroxicloroquine Antiviral medications like foscarnet, cidofovir and ribavirin were used as systemic HPV treatment with good results Figure 2.

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HPV by the numbers 30 A history of genital warts, a positive HPV test result, or medicaments papillomavirus cervical, vaginal, vulvar or anal cytology, all indicate a prior HPV infection, but not necessarily with the HPV types included in the vaccines. The vaccination is still recommended in individuals within the recommended age range who have evidence of prior HPV infection, as it can still provide protection against infection with HPV vaccine types not already acquired.

However, these patients should be advised that vaccination will have no therapeutic effect on preexisting HPV infection or in HPV-associated diseases, and the potential benefit of HPV vaccination is not as great as if they were vaccinated before their sexual debut 24, The therapeutic anti-HPV vaccines are supposed to induce cell-mediated immunity and to prevent medicaments papillomavirus development of benign and malignant lesions induced by this virus.

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Cell-mediated rather than humoral immune responses are important for the clearance of established infections. The HPV E6 medicaments papillomavirus E7 oncoproteins are essential for the onset and main­tenance of malignancy; thus, they are unlikely to escape immune responses by mutation. They medicaments papillomavirus also expressed constitutively and at high levels, and therefore represent near-ideal targets for the development of therapeutic vaccines against established HPV infections and lesions.

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Other proteins useful for targeting of early viral infec­tions are E1 viral helicase and E2, which are expressed at higher levels than E6 and E7 at very early stages before viral genome integration.